Because some of us have high levels of skepticism with that stuff. Even the GLP-1 inhibitors are too new to really get a handle on. The only proven methods to health are those that have existed before we ever came along: a clean diet and (good) exercise.
History shows time and time again that there are no free lunches in nature.
If anything, I need more reasons to leave the house. Not more reasons to stay inside and be on the computer even more.
I do agree that GLP-1s can't be a free lunch. It can't be that powerful for free. Even beyond that, we might not know what we are doing with them.
It use to be standard for testosterone replacement to get a shot from a doctor every two weeks. This is an unbelievably stupid way to take testosterone. Blasting a super physiologic level of testosterone and then crashing over a two week period would be a good way to amplify side effects if that were the goal but we didn't know what we were doing then.
It is very unlikely we would have just randomly stumbled on the best way to take GLP-1s out of the gate.
It wasn't a question of morality - we don't know what the long term side effects are.
Look if it helps a morbidly obese person drop enough weight so that they can get a handle on their A1C, blood pressure, etc. then it's probably (from what we know now) worth the risk. For the slightly overweight person who takes it, and I know a few from the gym, we don't know what that looks like yet.
It will take time to find out if there are long term detrimental effects.
JFYI, GLP-1 agonists have been in research and clinical use for about 20 years by now.
And while medical chemistry moves slowly, I have no doubt that we'll solve the exercise problem within the next decades. Never mind by the time we're talking about ascending on the Kardashev scale.
Sometimes I think that is what metformin and statins do, because weirdly enough both seem to blunt the exercise response. I’d love to take them but I already exercise.
We already have exercise mimetics in pre-clinical trials. If you can keep yourself fit with zero expenditure of time, why wouldn't you?